A Stochastic Approach to LDL-C Intensification
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Keywords

LDL-C
lipid intensification therapy
clinical benefit

Abstract

The transition from general guidelines to precision cardiovascular medicine requires tools that can model individual biological variance. This paper outlines the methodology of LipidLogic Pro v2.1, a simulation engine for predicting Absolute Risk Reduction (ARR) and Number Needed to Treat (NNT) following intensified lipid-lowering therapy. The engine utilizes a kinetic-based meta-regression approach derived from the Cholesterol Treatment Trialists’ (CTT) Collaboration.

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References

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4. Sabatine MS, et al. (FOURIER Steering Committee). Evolocumab and Clinical Outcomes in Patients with Cardiovascular Disease. N Engl J Med. 2017;376(18):1713-1722.

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This work is licensed under a Creative Commons Attribution 4.0 International License.

Copyright (c) 2025 Khaing Mar Lwin, Mahmood Ahmad, Tomi, Ata Ul Hayee Sohail