MCS-Logic v4.1

Analysis Presets

Exclude high arrest (>50%)

Trial Database 5 selected

Random Effects Meta-Analysis (DerSimonian-Laird)

0.87

0.74–1.03

Pooled HR

0.58–1.30

95% PI

Prediction Int

42%

τ²=0.03

Heterogeneity

924

5 trials

Population

0.10

Not significant

P-value

GRADE Assessment

Translation (per 100 patients)

📊 Clinical Impact

Lives Saved

Excess Deaths

Major Bleed

Standard Mort.

🎲 Monte Carlo Net Benefit

P(benefit)=68%

Sensitivity Parameters

Baseline 6-month mortality 55%

Bleeding OR multiplier 2.6×

Methodology: DerSimonian-Laird Random Effects.
Haldane-Anscombe correction applied for zero events.
NCB = ARR(mortality) - 0.3 × ARI(bleeding).