Knowledge Extraction and Local Utilization of Clinical Trial Evidence in Uganda: A Systematic Review and Meta-Analysis

Abstract

Introduction
The globalization of clinical research has increased trial activity in Africa, including Uganda, yet concerns persist about unequal knowledge flows. Evidence generated in African settings is often analysed and published in Northern institutions, limiting local access and utilization.

Objectives
To assess knowledge extraction and local utilization of clinical trial evidence in Uganda.

Methods
A systematic review and meta-analysis of trial registrations and publications used databases and bibliometric sources. The knowledge value chain from registration to application was analysed. The primary outcome was the knowledge-return ratio, measuring locally applied evidence.

Results
Seventy-two percent of data were analysed in Northern institutions, 65 percent of publications were paywalled, and only 18 percent were implemented locally.

Discussion
Findings indicate persistent imbalance and limited translation into Ugandan healthcare.