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2026-06-06

Synthēsis has been publishing open-access, peer-reviewed research since November 2025. Read more about Welcome to Synthēsis

Current Issue

Vol. 2 No. 4: June 2026

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Published: 2026-06-17

Short Meta-Analysis

Transcatheter Treatment for Severe Symptomatic Tricuspid Regurgitation: A Rapid Meta-Analysis of Randomised Evidence (2025)

Laiba Khan, Maham Khan, Muhammad Hamza Khan, Joanne Lac
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Research Article

AU Health Strategy Alignment and Inequality in African Clinical Trials: A Cross-Sectional Analysis of ClinicalTrials.gov Data

Justine Kirabo, Anna Nankabira, Shamim Nabidda, Aminah Mohamud Fidow, Christine Muhumuza, Ronnie Ssenfuma, Rhoda Chikula, Ruchius Philbert, Joshua Tulengerayo, Mukisa Paul Brian, Derrick Tumwesigye
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HIV Testing Services Uptake Among Adolescent Girls and Young Women in Sub-Saharan Africa: A Systematic Review and Meta-Analysis

Christine Muhumuza, Ruth Mpirirwe , Bridget Tamale , Michael Muhoozi
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Predatory Journal Risk and Structural Inequities in African Research Publishing: Implications for Uganda Predatory Journal Risk

Christine Muhumuza, Njeodo Njongang Vigny , Bitness Lyabagaga, Kanyesigye Edith , Amumpaire Olivia , Shamim Nabidda, Tukamushaba Bruce, Natinael Berhane, Eghaghe Osadebamwen Nibokun , Sebudde Nicholus, Munyole Samuel , Musoke Muhammad , Kirabo Jireh , Ruchius Philbert, Fadumo Said Hassan , Adrine Nyamwiza, Rhoda Chikula, Amina Mohamud Fidow, Ssenfuma Ronnie , Joy Osifo, Muhammad Murtala Yusuf , Tulengerayo Joshua, Mukisa Paul Brian, Anna Nakirabira , Derrick Tumwesigye , Kirabo Justine, Kumbukani Chikosa, Charles Bafaki
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Africa’s Youth Researcher Pipeline and Structural Inequities in Clinical Trial Leadership: Implications for Uganda and the African Continent. Youth Researcher Pipeline

Fadumo Said Hassan , Amumpaire Olivia , Kanyesigye Edith , Sebudde Nicholus , Musoke Muhammad , Christine Muhumuza, Shamim Nabidda , Samuel Munyole, Bruce Tukamushaba , Njongang Vigny Njeodo , Ruchius Philbert, Amina Fidow Mohamud , Osadebamwen Nibokun Eghaghe, Michael Antwi Bosiako , Adrine Nyamwiza, Ronnie Ssenfuma , Joy Osifo, Rhoda Chikula, Muhammad Murtala Yusuf , Tulengerayo Joshua , Natinael Berhane, Mukisa Paul Brian , Anna Nakirabira, Derrick Tumwesigye , Kirabo Justine
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SGLT2 Inhibitors in Heart Failure: Living Meta-Analysis Across the EF Spectrum

Hamood Saeed
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Vulnerable Population Protection: Structural Inequalities in Clinical Trial Investment

Joanitah Namatovu , Edith Kanyesigye, Martha Alice Namiiro , Bitness Lyabagaga , Olivia Amumpaire , Rhoda Chikula, Muhammad Musoke , Jireh Kirabo , Samuel Munyole , Osadebamwen Nibokun Eghaghe , Bruce Tukamushaba , Njongang Vigny Njeodo , Nicholus Sebudde , Amina Fidow Mohamud, Michael Antwi Bosiako , Christine Muhumuza , Fadumo Said Hassan , Adrine Nyamwiza , Ruchius Philbert, Ronnie Ssenfuma , Yusuf Murtala Muhammad , Berhane Natinael , Anna Nakirabira , Derrick Tumwesigye , Justine Kirabo , Kumbukani Chikosa , Joy Osifo , Natinael Berhane yeshanew , Joshua Tulengerayo
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Precision Medicine in Africa: A Systematic Review of Epilepsy Treatment Gap

Eleanor Sabuka
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Participant Compensation Ethics in African Trials: A Cross-Sectional Analysis of Trial Distribution and Ethical Implications

AMINA MOHAMUD FIDOW
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Sickle Cell Disease Neglect: A Mismatch Between Burden and Research in Africa

Peter Eyong Ebot, Randolf Fuanghene Wefuan, Jacob Muruhukye, Rita Ewah Mbah, Enu-Ma Obi-Asu , Spritney Nashua Ninpa, Liza Ting Tata , Rhoda Chikula, Grace Kemigisha , Gloria Margaret Nanono , Geofrey Emesu, Janepher Nabaasa , Ebere Olive Nwanja
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COVID-19 Displacement

OKUYO PATIENCE, Ruchius Philbert, Kindiki Agnes, Evelyn Nakuya
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The Bio-Digital Divide: Digital trial adoption and the Bio-digital gap in Africa

PETER EBOT EYONG, Jacob Muruhukye, Rita Ewah Mbah, Endurance Lum Ambe, Vahid Esangaya Ntoung-Mbi , Spritney Nashua Ninpa , Tata Liza Ting, Rhoda Chikula, Grace Kemigisha , Geofrey Emesu , Ronald Bwambale , Janepher Nabaasa , Ebere Olive Nwanja, Prossy Nabateregga , Gloria Margaret Nanono
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The Network Entropy and Structural Disorder in African Clinical Research: A Meta-Analysis Review

MAHAD MUWEESI, MALINGA ODONG, JOYCE NAYIGA, SOLOMON WANI
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Knowledge Extraction and Local Utilization of Clinical Trial Evidence in Uganda: A Systematic Review and Meta-Analysis

Adrine Nyamwiza
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Global RCT Equity: Africa vs. Europe

Geofrey Emesu, Lauritta Chinezaekpere Ndufeiya, Everlyn Nakuya, Ronald Bwambale, Peter Eyong Ebot, Gloria Margaret Nanono
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Decolonising Research

Derrick Tumwesigye; Ruchius Philbert; Christine Muhumuza
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Digital Health Trial Explosion and Structural Inequities in African Clinical Research: A Meta-Analysis Review

John Francis Kimuli, Ishmael Gumbo, Simachew Getaneh Endalamew, Frank Matovu
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Research Sovereignty in African Clinical Trials: A Network Analysis of Global North and Global South Partnerships.

Caroline Nakalema, Peter Mulindwa, Ahmad Mahmood
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SGLT2 Inhibitors and Heart Failure

maheen akbar
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Auditing the public clinical-trials record: a registry-integrity atlas of registration, reporting and completion gaps

Andrew Woo
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Africa Forecast: Causal Health Forecasting for 54 African Countries 2026-2036

Nakhabi Anna
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Severe Asthma Biologics Ultra-Precision — Living Meta-Analysis (RapidMeta)

Hamood Saeed
- HTML (interactive dashboard)
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JAK Inhibitors in Rheumatoid Arthritis — Living Meta-Analysis (RapidMeta)

Hamood Saeed
- HTML (interactive dashboard)
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Sotagliflozin SGLT1/2i: A Transparent Living Meta-Analysis v13

Sara Ahmed Ahmed
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Altruism Efficiency & Health Expenditure

Paul Brian Mukisa
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The Cyclical Pattern of Boom and Bust in Research Has Left Africa Unprepared for Emergencies Such as Ebola

Grace Kemigisha, Idah Mokeira Mirera, Evelyn Nakuya, Mohammad Murtala Yusuf, Prossy Nabateregga
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Community led Research

OKUYO PATIENCE, Ssanyu Josette M, Ruchius Philbert, Nabateregga Prossy, Evelyn Nakuya, Kindiki Agnes
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Effectiveness of Differentiated Service Delivery ART Care Among Priority Populations in Sub-Saharan Africa: Evidence from a Systematic Review and Meta-analysis

Christine Muhumuza, Ruchius Philbert, Tamale Bridget
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Effectiveness of Point-of-Care Viral Load Testing Among Priority Populations in Sub-Saharan Africa: Evidence from a Systematic Review and Meta-analysis

Christine Muhumuza, Ruchius Philbert, Tamale Bridget
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Effectiveness of PrEP Initiation Among Priority Populations in Sub-Saharan Africa: Evidence from a Systematic Review and Meta-analysis

Christine Muhumuza, Ruchius Philbert, Tamale Bridget
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Effectiveness of HIV Self-Testing Among Priority Populations in Sub-Saharan Africa: Evidence from a Systematic Review and Meta-analysis

Christine Muhumuza, Ruchius Philbert, Bridget Tamale
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SGLT2 Inhibitors and Heart Failure Outcomes Across the Ejection Fraction Spectrum; a Systematic Review and Meta-Analysis

John Kokas Obwiin
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Pharma Continental Pipeline

Amumpaire Olivia, Bitness Lyabagaga, Njeodo Njongang Vigny, Natinael Berhane, Sebudde Nicholus, Musoke Muhammad, Kirabo Jireh, Muhammad Murtala, Shamim Nabidda, Tukamushaba Bruce, Munyole Samuel, Eghaghe Osadebamwen, Kumbukani Chikosa, Michael Bosiako Antwi , Christine Muhumuza, Fadumo Said Hassan, Adrine Nyamwiza, Ruchius Philbert, Rhoda Chikula, Amina Mohamud Fidow, Ssenfuma Ronnie, Joy Osifo, Tulengerayo Joshua, Mukisa Paul Brian, Derrick Tumwesigye, Kirabo Justine
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Community advisory structure in African clinical trials: A registry-based analysis

Peter Eyong Ebot, Jacob Muruhukye, James Mukiibi, Spritney Nashua Ninpa , Christopher Tibamwenda, Meldwinel Ayuk , Vahid Esangaya Ntoung-Mbi , Endurance Lum Ambe, Rhoda Chikula, Paul Brian Mukisa, Grace Kemigisha , Gloria Margaret Nanono , Geofrey Emesu , Muhammad Murtala Yusuf, Ronald Bwambale Ronald, Janepher Nabaasa , Nwanja Ebere Olive, Prossy Nabateregga
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Efficacy and Safety of Intravenous Calcium Pretreatment Prior to Nondihydropyridine Calcium Channel Blockers in Atrial Fibrillation or Flutter: A Comparative Synthesis

Majed Sheikh, Shiva Narain Thiagarajan, Shruthi Karthikeyan, Mahmood Ahmad
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WHO Alignment and Disease Burden Gaps

Michael Bosiako Antwi, Njeodo Njongang Vigny , Shamim Nabidda , Tukamushaba Bruce , Christine Muhumuza , Fadumo Said Hassan , Ruchius Philbert, Rhoda Chikula , Amina Mohamud Fidow , Ssenfuma Ronnie
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Identifying a New Typology of European Health Systems

Poe Hnin Phyu, Laiba Khan, Maham Khan, Nijat Rizayev, Manpreet Kour, Touqeer Rana, Andrew Woo, Parichatra Homhuan
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Global CVD Trends and Regional Risk‐Profile Clustering Using GBD 2022 Data Global CVD Trends

Laiba Khan, Maham KHAN, Muhammad Hamza KHAN, Joanne Lac
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Forecasting National Non-Communicable Disease Mortality Using Machine Learning: An Ecological Study of Predictive Factors

Laiba Khan, Maham KHAN, Muhammad Hamza KHAN, Joanne Lac
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Dynamics of Zoonotic Disease at the One Health Interface: Evidence from a Systematic Review

Nakhabi Anna, Jacob Muruhukye, Eleanor Sabuka, Christopher Tibamwenda, Lauritta Chinazaekpere Ndufeiya, Gloria Margaret, Nanono, Muhammad Murtala Yusuf, Grace Kemigisha , Phiona Obbo, Peter Ebot Eyong, Prossy Nabateregga , Nwanja Olive Ebere
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Applying Placebo Ethics Audit findings to Uganda: Health System Challenges and Ethical Consideration in Clinical Trials

Fadumo Said Hassan
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The Breast Cancer Clinical Trial Disparities in Africa: Limited Evidence for a High-Burden Population Limited Evidence for a High-Burden Population

Janepher Nabaasa, Nabaasa Janepher, Eyong Peter
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Network Centrality and Research Sovereignty in African Clinical Trials: Evidence from a Global Registry Analysis

Alice Martha Namiiro, Micheal Bosaiko, Njeodo Njongang Vigny, Shamim Nabidda, Bruce Tukamushaba, Eghaghe Osadebamwen Nibokun, Anna Nakirabira, Jireh Kirabo, Nicholus Sebudde, Olivia Amumpaire, Joanitah Namatovu, Edith Kanyesigye, Bitness Edward Lyabagaga, Samuel Munyole, Muhammad Musoke, Christine Muhumuza, Fadumo Said Hassan, Ruchius Philbert, Rhoda Chikula, Amina Mohamud Fidow, Ronnie Ssenfuma, Joy Osifo, Muhammad Murtala Yusuf, Joshua Tulengerayo, Natineal Berhane, Paul Brian Mukisa, Adrine Nyamwiza
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Structural Inequity in Research Investment and Africa’s Readiness for Platform Trials: A Meta-Analysis

Zelda Sandra Mwebe, Felix Kofi Awuriki, Kimuli John Francis
- HTML (interactive dashboard)
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The Cervical Cancer HPV Gap

Muhammad Murtala Yusuf, Zainab Abdulazeez , Fatima Abdullahi Hari, Rukayya Ado Bello, Shamsudeen Shuaibu, Grace Kemigisha, Eyong Peter Ebot
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Research Archetypes and Cluster Mapping Narratives: A Semantic Comparison of Africa and Europe Understanding innovation and evaluation framing in global Research Archetypes and Cluster Mapping

Agnes Kindiki, Tibamwenda Christopher, Muruhukye Jacob, Kindiki Agnes, Nabateregga Prossy, Eyong Peter Ebot
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Beyond the Gap: 80% Use, 0.0% Trials — The Traditional Medicine Research Void Across Africa Traditional Medicine Integration

Grace Kemigisha, Anna Nakhabi, Evelyn Nakuya, Peter Eyong Ebot, Mohammad Murtala Yusuf; Gloria Margaret Nanono
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Health and Disease Burden Antimicrobial Resistance Crisis

Gloria Margaret Nanono, Christopher Tibamwenda, Jacob Muruhukye, Grace Kemigisa, Peter Ebot Eyong, Fiona Obbo, Prossy Nabateregga
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Assessment of PEPFAR Funding Reduction on the Quality of HIV Services at Sex Workers Outreach Program Clinics, Nairobi County, Kenya

Idah Mirera, Caroline Kawila, Jonathan Monda
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HIV Trial Saturation Index

Idah Mirera, Everlyne Nakuya, Nabaasa Janepher, Eyong Ebot, Fadumo Hassan
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Informed Consent Language and Structural Inequity in African Clinical Trial Governance: A Cross-Sectional Audit

Ivan Mutyaba, Njeodo Njongang Vigny, Amumpaire Olivia, Sebudde Nicholus, Ruchius Philbert, Kirabo Jireh, Munyole Samuel, Tukamushaba Bruce, Shamim Nabidda, Martina Uisso, Tom Okade, Huzaifah Mutyaba, Musoke Muhammad, Eghaghe Osadebamwen Nibokum, Michael Bosiako Antwi, Christine Muhumuza, Fadumo Said Hassan, Rhoda Chikula, Amina Mohamud Fidow, Anna Nakirabira, Mukisa Paul Brian, Natinael Berhane, Tulengerayo Joshua, Muhammad Murtala Yusuf, Joy Osifo, Ssenfuma Ronnie
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Artificial Intelligence in Clinical Trials: A Cross-Sectional Analysis of Structural Inequities in African and United States Research Investment

Frank Matovu, Lauryn Nsenga, Simachew Getaneh Endalamew, Mary Nafuna
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Precision Medicine in Africa: A Systematic Review of Genomic Resilience and Structural Gaps

Muruhukye Jacob, Eleanor Sabuka, Anna Nakhabi, Mukisa Paul Brian, Nanono Gloria Margaret, Nabateregga Prossy, Eyong Peter Ebot
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Geographic Inequity in African Clinical Trials: A Systematic Review Evidence of a Port-City Advantage

John Kokas Obwiin
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Sample Size Adequacy Audit

Joy Osifo
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Inequities in Clinical Trial Distribution for Neglected Tropical Diseases: A Cross-Sectional Analysis of Global Research Concentration

Ronald Bwambale, Mutebi, Nelson Nsubuga, Janepher Nabaasa, Aggrey Gavamukulya, Persis Tikabulamu, Geofrey Emesu, Phiona Obbo
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Diamond open-access journal for concise, reproducible medical evidence synthesis

Synthēsis publishes concise, reproducible evidence syntheses and structured methods notes, each linked to its data. No author or reader fees · CC BY 4.0 · authors retain copyright.

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